The 1959 Bucknell Bison football team was an American football team that represented Bucknell University during the 1959 college football season. Bucknell finished fourth in the University Division of the Middle Atlantic Conference.

In its second season under head coach Bob Odell, the team compiled a 4–5 record,^[1] 3–3 against division opponents. Larry Mathias was the team captain.^[2]

Following their defeat of Rutgers, an NCAA University Division team, Bucknell earned a national No. 11 ranking in the UPI small college poll. The following week, the Bison lost to unranked Lafayette, and were pushed out of the top 20. Bucknell remained unranked through the end of the season.

The team played its home games at Memorial Stadium on the university campus in Lewisburg, Pennsylvania.

Date	Opponent	Site	Result	Attendance	Source
September 26	vs. Gettysburg	Hershey Stadium Hershey, PA (Rotary Bowl)	W 21–0	8,500	[3]
October 3	at Harvard*	Harvard Stadium Boston, MA	L 6–20	9,000	[4]
October 10	No. 5 Buffalo*	Memorial Stadium Lewisburg, PA	W 26–21	5,000	[5]
October 17	Rutgers	Memorial Stadium Lewisburg, PA	W 15–8	10,000	[6]
October 24	at Lafayette	Fisher Field Easton, PA	L 6–12	8,000–9,500	[7][8]
October 31	at Lehigh	Taylor Stadium Bethlehem, PA	L 0–14	4,600	[9]
November 7	at Colgate*	Colgate Athletic Field Hamilton, NY	L 13–16	4,000	[10]
November 14	Temple	Memorial Stadium Lewisburg, PA	W 26–6	4,500	[1]
November 21	No. 4 Delaware	Memorial Stadium Lewisburg, PA	L 6–22	8,000	[11]
*Non-conference game Homecoming Rankings from UPI Poll released prior to the game

^[12]