The 2001 San Jose State Spartans football team represented San Jose State University as a member of the Western Athletic Conference (WAC) the 2001 NCAA Division I-A football season. Led by first-year head coach Fitz Hill, the Spartans compiled an overall record of 3–9 with a mark of 3–5 in conference play, tying for seventh place in the WAC. San Jose State played home games at Spartan Stadium in San Jose, California.

Date	Time	Opponent	Site	TV	Result	Attendance
September 1	3:30 p.m.	at USC*	Los Angeles Memorial Coliseum Los Angeles, CA	FSW2, FSNBA	L 10–21	45,568
September 8	12:30 p.m.	at Colorado*	Folsom Field Boulder, CO		L 15–51	40,338
September 29	7:15 p.m.	at Arizona State*	Sun Devil Stadium Tempe, AZ	FSAZ	L 15–53	45,528
October 6	4:00 p.m.	at Louisiana Tech	Joe Aillet Stadium Ruston, LA		L 20–41	19,236
October 13	2:00 p.m.	SMU	Spartan Stadium San Jose, CA		L 17–24	8,329
October 20	6:00 p.m.	at UTEP	Sun Bowl El Paso, TX		W 40–28	30,048
October 27	2:00 p.m.	Tulsa	Spartan Stadium San Jose, CA		W 63–27	6,873
November 3	8:00 p.m.	at Hawaii	Aloha Stadium Halawa, HI (Dick Tomey Legacy Game)	KFVE	L 10-34	36,566
November 10	3:30 p.m.	Nevada	Spartan Stadium San Jose, CA		W 64–45	7,882
November 17	12:00 p.m.	at Boise State	Bronco Stadium Boise, ID		L 6–56	24,388
November 23	1:00 p.m.	at No. 23 Fresno State	Bulldog Stadium Fresno, CA (rivalry)		L 21–40	42,881
December 1	2:00 p.m.	No. 12 Stanford*	Spartan Stadium San Jose, CA (rivalry)		L 14–41	17,745
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Pacific time

• A. ^ The game against Nevada was originally to be played on September 22 but was rescheduled.^[1]
• B. ^ The game against Stanford was originally to be played on September 15 but was rescheduled because of the September 11 attacks.^[2]