The 2000 Major League Baseball season ended with the New York Yankees defeating the New York Mets in five games, for their third consecutive World Series title.^[1] The 2000 World Series was known as the Subway Series because both fans and the two teams could take the subway to and from every game of the series.^[2]

A then-record 5,693 home runs were hit during the regular season in 2000 (the record was broken in 2017, when 6,105 home runs were hit).^[1] Ten teams hit at least 200 home runs each,^[3] while for the first time since 1989 and only the fifth since 1949 no pitcher pitched a no-hitter. Also, no team reached 100 in either the win or loss column.

The separate American and National League offices were dissolved; with this, Major League Baseball became a single unified organization. As a result, the separate umpiring crews for each league were also dissolved; all umpiring crews now worked throughout the league.

Standings