Clindamycin/tretinoin

Clindamycin/tretinoin
Combination of
Clindamycin phosphate	Antibiotic
Tretinoin	Topical retinoid
Clinical data
Trade names	Ziana, Veltin, Acnatac, others
MedlinePlus	a609005
License data	US FDA: Ziana;
Routes of; administration	Topical
ATC code	D10AD51 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
CAS Number	337954-93-5;
KEGG	D11084;
	(verify)

Clindamycin/tretinoin is a topical gel used in the treatment of acne. The two active ingredients are the antibiotic clindamycin phosphate (1.2%) and tretinoin (0.025%), a retinoid.^[1] The two active ingredients perform different functions, the clindamycin is active against gram-positive bacteria, including streptococci and penicillin-resistant staphylococci.^[2] The Tretinoin element acts to reduce the amount of oil released by oil glands in skin, as well as encouraging skin cell replenishment.^[3] The topical treatment is stored in 2, 30, and 60 gram tubes and should be stored at 25°C (77°F), with the tube tightly shut away from light.^[4] Side effects may include peeling, redness, dryness, itching and photosensitivity. Also, topical clindamycin may rarely cause diarrhea or colitis. Sun exposure while using this preparation can cause skin irritation.^[5]

Citations

^ "Ziana Gel". Retrieved 2008-11-16.
^ "BNF is only available in the UK". NICE. Retrieved 2021-10-05.
^ Zasada M, Budzisz E (August 2019). "Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments". Postepy Dermatologii I Alergologii. 36 (4): 392–397. doi:10.5114/ada.2019.87443. PMC 6791161. PMID 31616211.
^ "ZIANA Prescribing Information" (PDF). Archived from the original (PDF) on 2007-06-17. Retrieved 2008-11-15.
^ Kurokawa, Ichiro (2016-05-19). "Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris". doi:10.3410/f.726161029.793518600. {{cite journal}}: Cite journal requires |journal= (help)

External links

Official Website

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[1] "Ziana Gel". Retrieved 2008-11-16.

[2] "BNF is only available in the UK". NICE. Retrieved 2021-10-05.

[3] Zasada M, Budzisz E (August 2019). "Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments". Postepy Dermatologii I Alergologii. 36 (4): 392–397. doi:10.5114/ada.2019.87443. PMC 6791161. PMID 31616211.

[4] "ZIANA Prescribing Information" (PDF). Archived from the original (PDF) on 2007-06-17. Retrieved 2008-11-15.

[5] Kurokawa, Ichiro (2016-05-19). "Faculty Opinions recommendation of Guidelines of care for the management of acne vulgaris". doi:10.3410/f.726161029.793518600. {{cite journal}}: Cite journal requires |journal= (help)

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v t e Acne-treating agents (D10)
Antibacterial	Azelaic acid Benzoyl peroxide^# 8-Hydroxyquinoline Blue light therapy Tea tree oil
Keratolytic	Glycolic acid Salicylic acid^# Sulfur Benzoyl peroxide^#
Anti-inflammatory	Niacinamide Ibuprofen^# Aspirin^# Red light therapy
Antibiotics	Clindamycin Dapsone Erythromycin Sulfacetamide Tetracyclines (Lymecycline Minocycline Doxycycline)
Hormonal	Antiandrogens Bicalutamide Cyproterone acetate Drospirenone Flutamide Spironolactone) Estrogens Estradiol Ethinylestradiol
Retinoids	Adapalene Isotretinoin Motretinide Tazarotene Tretinoin Trifarotene
Other	Epristeride Mesulfen Pelretin Stridex Tioxolone
Combinations	Adapalene/benzoyl peroxide Clindamycin/adapalene/benzoyl peroxide Clindamycin/benzoyl peroxide Clindamycin/tretinoin Erythromycin/benzoyl peroxide Erythromycin/isotretinoin Sulfacetamide/sulfur Tretinoin/benzoyl peroxide
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III