Cornea verticillata

Cornea verticillata
Cornea verticillata
Other names	Fleischer vortex
	Cornea verticillata: A bilateral, whorl-like corneal pattern of cream colored lines in a patient with Fabry disease.
Specialty	Ophthalmology
Treatment	Discontinuation of the offending drug results in complete resolution of the opacity.

Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern.^[2] It is seen in Fabry disease or in case of prolonged amiodarone intake.^[3] Furthermore, it is a common adverse side effect of the use of rho-kinase inhibitors in glaucoma therapy.^[4]

Presentation

No ocular complaints or visual difficulty is usually present.^[3]^[5]

Pathophysiology

This keratopathy is probably a type of drug-induced lipidosis.^[3]

Diagnosis

References

^ "Definition: 'Cornea Verticillata'". MediLexicon. Retrieved 29 November 2013.
^ van der Tol, Linda; Sminia, Marije L; Hollak, Carla E M; Biegstraaten, Marieke (2016). "Cornea verticillata supports a diagnosis of Fabry disease in non-classical phenotypes: results from the Dutch cohort and a systematic review". British Journal of Ophthalmology. 100 (1): 3–8. doi:10.1136/bjophthalmol-2014-306433. ISSN 0007-1161. PMID 25677671.
^ ^a ^b ^c Chew, E; Ghosh, M; McCulloch, C (June 1982). "Amiodarone-induced cornea verticillata". Canadian Journal of Ophthalmology. 17 (3): 96–9. PMID 7116220.
^ Rivera, Sean S.; Radunzel, Nicole; Boese, Erin A. (2023-11-01). "Symptomatic Netarsudil-Induced Verticillata". JAMA Ophthalmology. 141 (11): e232949. doi:10.1001/jamaophthalmol.2023.2949. ISSN 2168-6173. PMID 37971506. S2CID 265267017.
^ Graff, Jordan M. (February 21, 2005). "Verticillata". University of Iowa Health Care, Ophthalmology and Visual Sciences. Retrieved 29 November 2013.

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[1] "Definition: 'Cornea Verticillata'". MediLexicon. Retrieved 29 November 2013.

[van_der_TolSminia2016-2] van der Tol, Linda; Sminia, Marije L; Hollak, Carla E M; Biegstraaten, Marieke (2016). "Cornea verticillata supports a diagnosis of Fabry disease in non-classical phenotypes: results from the Dutch cohort and a systematic review". British Journal of Ophthalmology. 100 (1): 3–8. doi:10.1136/bjophthalmol-2014-306433. ISSN 0007-1161. PMID 25677671.

[pmid7116220-3] Chew, E; Ghosh, M; McCulloch, C (June 1982). "Amiodarone-induced cornea verticillata". Canadian Journal of Ophthalmology. 17 (3): 96–9. PMID 7116220.

[4] Rivera, Sean S.; Radunzel, Nicole; Boese, Erin A. (2023-11-01). "Symptomatic Netarsudil-Induced Verticillata". JAMA Ophthalmology. 141 (11): e232949. doi:10.1001/jamaophthalmol.2023.2949. ISSN 2168-6173. PMID 37971506. S2CID 265267017.

[5] Graff, Jordan M. (February 21, 2005). "Verticillata". University of Iowa Health Care, Ophthalmology and Visual Sciences. Retrieved 29 November 2013.

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Cornea verticillata
Other names	Fleischer vortex^[1]

Cornea verticillata: A bilateral, whorl-like corneal pattern of cream colored lines in a patient with Fabry disease.
Specialty	Ophthalmology
Treatment	Discontinuation of the offending drug results in complete resolution of the opacity.