A | B | C | D | E | F | G | H | CH | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9
Combination of | |
---|---|
Darunavir | HIV protease inhibitor |
Cobicistat | Cytochrome P450 (CYP3A) inhibitor |
Clinical data | |
Trade names | Rezolsta, Prezcobix |
AHFS/Drugs.com | Professional Drug Facts |
License data | |
Pregnancy category |
|
Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
PubChem CID | |
UNII | |
KEGG | |
Chemical and physical data | |
Formula | C67H90N10O12S3 |
Molar mass | 1323.70 g·mol−1 |
3D model (JSmol) | |
| |
|
Darunavir/cobicistat, sold under the brand names Prezcobix (US) and Rezolsta (EU), is a fixed-dose combination antiretroviral medication used to treat and prevent HIV/AIDS.[3] It contains darunavir and cobicistat.[3][5][6] Darunavir is an HIV protease inhibitor and cobicistat increases the effectiveness of darunavir by blocking its metabolism by the enzyme CYP3A.[6][3]
Darunavir/cobicistat was approved for use in the European Union in November 2014, and for use in the United States in January 2015.[4][7][8][3][9]
References
- ^ "Cobicistat / darunavir (Prezcobix) Use During Pregnancy". Drugs.com. 25 June 2019. Retrieved 19 February 2020.
- ^ "Drug and medical device highlights 2018: Helping you maintain and improve your health". Health Canada. 14 October 2020. Retrieved 17 April 2024.
- ^ a b c d e "Prezcobix- darunavir ethanolate and cobicistat tablet, film coated". DailyMed. 6 June 2019. Retrieved 20 February 2020.
- ^ a b "Rezolsta EPAR". European Medicines Agency (EMA). Retrieved 4 April 2020.
- ^ "Darunavir / Cobicistat". AIDSinfo. U.S. Department of Health and Human Services. Archived from the original on 3 March 2020. Retrieved 29 June 2018.
- ^ a b "Darunavir and Cobicistat (Professional Patient Advice)". Drugs.com. 16 September 2019. Retrieved 19 February 2020.
- ^ "Antiretroviral drugs used in the treatment of HIV infection". U.S. Food and Drug Administration (FDA). 12 April 2018. Retrieved 19 February 2020.
- ^ "Darunavir/Cobicistat (Prezcobix) Combo Pill Clears FDA". Medscape. 30 January 2015.
- ^ "Prezcobix (darunavir and cobicistat) Tablet". U.S. Food and Drug Administration (FDA). 15 June 2016. Retrieved 4 April 2020.
External links
- "Cobicistat". MedlinePlus.
- "Darunavir". MedlinePlus.
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