Isolated organ perfusion technique

Isolated organ perfusion technique is employed to precipitate an organ's perfusion and circulation that are independent/isolated from the body's systemic circulation for various purposes such as organ-localized chemotherapy, organ-targeted delivery of drug, gene or anything else, organ transplantation, and organ injury recovery. The technique has been widely studied in animal and human for decades.^[1]^[2]^[3]^[4]^[5]^[6]^[7] Before the implementation, the perfusion system will be selected and the process can be similar to organ bath.^[8] Isolated organ perfusion technique, nevertheless, is averagely conducted in vivo without leaving the organ alone as a whole out of the body.^[9]

References

^ Cypel, Marcelo; Keshavjee, Shaf (2016). "Novel Technologies for Isolated Lung Perfusion". Thoracic Surgery Clinics. 26 (2). Elsevier BV: 139–145. doi:10.1016/j.thorsurg.2015.12.002. ISSN 1547-4127. PMID 27112253.
^ Eiseman, B.; Knipe, Peter; McCOLL, H. A.; Orloff, M. J. (1961-09-01). "Isolated Liver Perfusion for Reducing Blood Ammonia". Archives of Surgery. 83 (3): 356–363. doi:10.1001/archsurg.1961.01300150030004. ISSN 0004-0010. PMID 13726167. Retrieved 2019-06-30.
^ "Isolated Organ Perfusion Studies - Physiology". Harvard Apparatus. Archived from the original on 2019-05-13. Retrieved 2019-06-30.
^ Abbott, William M.; Weinerth, John L. (1971). "The perfusion of isolated whole organs". Cryobiology. 8 (2). Elsevier BV: 113–133. doi:10.1016/0011-2240(71)90019-8. ISSN 0011-2240. PMID 5578880.
^ Guyette, Jacques P; Gilpin, Sarah E; Charest, Jonathan M; Tapias, Luis F; Ren, Xi; Ott, Harald C (2014-05-29). "Perfusion decellularization of whole organs". Nature Protocols. 9 (6). Springer Science and Business Media LLC: 1451–1468. doi:10.1038/nprot.2014.097. ISSN 1754-2189. PMID 24874812. S2CID 7397409.
^ Schjørring, Olav L.; Carlsson, Rune; Simonsen, Ulf (2015). "Pressure Myography to Study the Function and Structure of Isolated Small Arteries". Methods in Mouse Atherosclerosis. Methods in Molecular Biology. Vol. 1339. New York, NY: Springer New York. pp. 277–295. doi:10.1007/978-1-4939-2929-0_19. ISBN 978-1-4939-2928-3. ISSN 1064-3745. PMID 26445796.
^ Serrat, Maria A (2009-11-05). "Measuring bone blood supply in mice using fluorescent microspheres". Nature Protocols. 4 (12). Springer Science and Business Media LLC: 1749–1758. doi:10.1038/nprot.2009.190. ISSN 1754-2189. PMID 19893510. S2CID 29637802.
^ "Tissue bath" (PDF). Archived (PDF) from the original on 2017-06-18. Retrieved 2019-06-30.
^ Yeh, T.; Wechsler, A. S. (1998). "The Isolated Organ in Research". Surgical Research. New York, NY: Springer New York. pp. 435–452. doi:10.1007/978-1-4612-1888-3_49. ISBN 978-1-4612-7325-7. Technological advances in artificial perfusion allow effective isolated perfusion of a wide variety of organs and tissues, including, but not limited to, brain, heart, lung, heart-lung, liver, kidney, spleen, pancreas, thymus, gastrointestinal tract, urinary tract, reproductive tract, skeletal muscle, nerves, and blood vessels.

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[Cypel_Keshavjee_2016_pp._139–145-1] Cypel, Marcelo; Keshavjee, Shaf (2016). "Novel Technologies for Isolated Lung Perfusion". Thoracic Surgery Clinics. 26 (2). Elsevier BV: 139–145. doi:10.1016/j.thorsurg.2015.12.002. ISSN 1547-4127. PMID 27112253.

[Eiseman_Knipe_McCOLL_Orloff_1961_pp._356–363-2] Eiseman, B.; Knipe, Peter; McCOLL, H. A.; Orloff, M. J. (1961-09-01). "Isolated Liver Perfusion for Reducing Blood Ammonia". Archives of Surgery. 83 (3): 356–363. doi:10.1001/archsurg.1961.01300150030004. ISSN 0004-0010. PMID 13726167. Retrieved 2019-06-30.

[Harvard_Apparatus-3] "Isolated Organ Perfusion Studies - Physiology". Harvard Apparatus. Archived from the original on 2019-05-13. Retrieved 2019-06-30.

[Abbott_Weinerth_1971_pp._113–133-4] Abbott, William M.; Weinerth, John L. (1971). "The perfusion of isolated whole organs". Cryobiology. 8 (2). Elsevier BV: 113–133. doi:10.1016/0011-2240(71)90019-8. ISSN 0011-2240. PMID 5578880.

[Guyette_Gilpin_Charest_Tapias_pp._1451–1468-5] Guyette, Jacques P; Gilpin, Sarah E; Charest, Jonathan M; Tapias, Luis F; Ren, Xi; Ott, Harald C (2014-05-29). "Perfusion decellularization of whole organs". Nature Protocols. 9 (6). Springer Science and Business Media LLC: 1451–1468. doi:10.1038/nprot.2014.097. ISSN 1754-2189. PMID 24874812. S2CID 7397409.

[Schjørring_Carlsson_Simonsen_2015_pp._277–295-6] Schjørring, Olav L.; Carlsson, Rune; Simonsen, Ulf (2015). "Pressure Myography to Study the Function and Structure of Isolated Small Arteries". Methods in Mouse Atherosclerosis. Methods in Molecular Biology. Vol. 1339. New York, NY: Springer New York. pp. 277–295. doi:10.1007/978-1-4939-2929-0_19. ISBN 978-1-4939-2928-3. ISSN 1064-3745. PMID 26445796.

[Serrat_pp._1749–1758-7] Serrat, Maria A (2009-11-05). "Measuring bone blood supply in mice using fluorescent microspheres". Nature Protocols. 4 (12). Springer Science and Business Media LLC: 1749–1758. doi:10.1038/nprot.2009.190. ISSN 1754-2189. PMID 19893510. S2CID 29637802.

[8] "Tissue bath" (PDF). Archived (PDF) from the original on 2017-06-18. Retrieved 2019-06-30.

[Yeh_Wechsler_1998_pp._435–452-9] Yeh, T.; Wechsler, A. S. (1998). "The Isolated Organ in Research". Surgical Research. New York, NY: Springer New York. pp. 435–452. doi:10.1007/978-1-4612-1888-3_49. ISBN 978-1-4612-7325-7. Technological advances in artificial perfusion allow effective isolated perfusion of a wide variety of organs and tissues, including, but not limited to, brain, heart, lung, heart-lung, liver, kidney, spleen, pancreas, thymus, gastrointestinal tract, urinary tract, reproductive tract, skeletal muscle, nerves, and blood vessels.

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See also

References