Leukotriene B4 receptor 1

LTB4R
Identifiers
Aliases	LTB4R, BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7, leukotriene B4 receptor
External IDs	OMIM: 601531; MGI: 1309472; HomoloGene: 22477; GeneCards: LTB4R; OMA:LTB4R - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,318,036 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	56,005,951 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; blood; ; skin of leg; ; monocyte; ; granulocyte; ; spleen; ; vagina; ; olfactory zone of nasal mucosa; ; bone marrow; ; minor salivary glands;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; lip; ; bone marrow; ; skin of external ear; ; jejunum; ; embryo; ; embryo; ; blood; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; G protein-coupled peptide receptor activity; G protein-coupled receptor activity; leukotriene receptor activity; signal transducer activity; leukotriene B4 receptor activity; galanin receptor activity;
Cellular component	integral component of membrane; membrane raft; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; leukotriene signaling pathway; muscle contraction; neuropeptide signaling pathway; immune response; signal transduction; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	1241
	16995
	ENSG00000213903; ENSG00000285456
	ENSMUSG00000046908
	Q15722
	O88855
	NM_181657; NM_001143919
	NM_008519
	NP_001137391; NP_858043
	NP_032545
	Wikidata
View/Edit Human	View/Edit Mouse

Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.^[5]^[6]^[7]

References

^ ^a ^b ^c ENSG00000285456 GRCh38: Ensembl release 89: ENSG00000213903, ENSG00000285456 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046908 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Owman C, Nilsson C, Lolait SJ (Feb 1997). "Cloning of cDNA encoding a putative chemoattractant receptor". Genomics. 37 (2): 187–94. doi:10.1006/geno.1996.0541. PMID 8921391.
^ Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem. 271 (31): 18363–7. doi:10.1074/jbc.271.31.18363. PMID 8702478.
^ "Entrez Gene: LTB4R leukotriene B4 receptor".

Raport CJ, Schweickart VL, Chantry D, et al. (1996). "New members of the chemokine receptor gene family". J. Leukoc. Biol. 59 (1): 18–23. doi:10.1002/jlb.59.1.18. PMID 8558062. S2CID 24239900.
Tager AM, Luster AD (2004). "BLT1 and BLT2: the leukotriene B(4) receptors". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2–3): 123–34. doi:10.1016/S0952-3278(03)00073-5. PMID 12895595.
Miyahara N, Miyahara S, Takeda K, Gelfand EW (2006). "Role of the LTB4/BLT1 pathway in allergen-induced airway hyperresponsiveness and inflammation". Allergology International. 55 (2): 91–7. doi:10.2332/allergolint.55.91. PMID 17075244.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Yokomizo T, Izumi T, Chang K, et al. (1997). "A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis". Nature. 387 (6633): 620–4. Bibcode:1997Natur.387..620Y. doi:10.1038/42506. PMID 9177352. S2CID 4307104.
Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochem. Biophys. Res. Commun. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
Gaudreau R, Le Gouill C, Métaoui S, et al. (1998). "Signalling through the leukotriene B4 receptor involves both alphai and alpha16, but not alphaq or alpha11 G-protein subunits". Biochem. J. 335 (1): 15–8. doi:10.1042/bj3350015. PMC 1219746. PMID 9742207.
Kato K, Yokomizo T, Izumi T, Shimizu T (2000). "Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene". J. Exp. Med. 192 (3): 413–20. doi:10.1084/jem.192.3.413. PMC 2193224. PMID 10934229.
Yokomizo T, Kato K, Terawaki K, et al. (2000). "A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders". J. Exp. Med. 192 (3): 421–32. doi:10.1084/jem.192.3.421. PMC 2193217. PMID 10934230.
Stankova J, Turcotte S, Harris J, Rola-Pleszczynski M (2002). "Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival". J. Immunol. 168 (7): 3570–6. doi:10.4049/jimmunol.168.7.3570. PMID 11907121.
Gaudreau R, Le Gouill C, Venne MH, et al. (2002). "Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization". J. Biol. Chem. 277 (35): 31567–76. doi:10.1074/jbc.M202723200. PMID 12077128.
Hennig R, Ding XZ, Tong WG, et al. (2002). "5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue". Am. J. Pathol. 161 (2): 421–8. doi:10.1016/S0002-9440(10)64198-3. PMC 1850753. PMID 12163367.
Ito N, Yokomizo T, Sasaki T, et al. (2003). "Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release". J. Biol. Chem. 277 (47): 44898–904. doi:10.1074/jbc.M208051200. PMID 12244116.
Tong WG, Ding XZ, Hennig R, et al. (2003). "Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells". Clin. Cancer Res. 8 (10): 3232–42. PMID 12374694.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yokomizo T, Noiri E, Izumi T, Shimizu T (2003). "In Vivo Chemotaxis Using Cho Cells Expressing Human Leukotriene B4 Receptor". Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology. Vol. 507. pp. 357–61. doi:10.1007/978-1-4615-0193-0_55. ISBN 978-1-4613-4960-0. PMID 12664610.

External links

"Leukotriene Receptors: BLT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2013-03-14. Retrieved 2008-12-05.
LTB4R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Receptors,+Leukotriene+B4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] ENSG00000285456 GRCh38: Ensembl release 89: ENSG00000213903, ENSG00000285456 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046908 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8921391-5] Owman C, Nilsson C, Lolait SJ (Feb 1997). "Cloning of cDNA encoding a putative chemoattractant receptor". Genomics. 37 (2): 187–94. doi:10.1006/geno.1996.0541. PMID 8921391.

[pmid8702478-6] Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP (Sep 1996). "Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells". J Biol Chem. 271 (31): 18363–7. doi:10.1074/jbc.271.31.18363. PMID 8702478.

[entrez-7] "Entrez Gene: LTB4R leukotriene B4 receptor".

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See also

References

Further reading

External links