NSP2 (rotavirus)

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

NSP2 (rotavirus)
NSP2 (rotavirus)
	NSP2 octamer, human rotavirus, PDB: 2gu0.
Identifiers
Symbol	Rota_NS35
Pfam	PF02509
InterPro	IPR003668
CATH	2gu0
SCOP2	2r7j / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
	Protein folds into two domains.

NSP2 (NS35), is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.^[1] NSP2 is closely associated in vivo with the viral replicase.^[2] The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.^[3]

References

^ Kattoura MD, Chen X, Patton JT (August 1994). "The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase". Virology. 202 (2): 803–813. doi:10.1006/viro.1994.1402. PMID 8030243.
^ Aponte C, Poncet D, Cohen J (February 1996). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2". Journal of Virology. 70 (2): 985–91. doi:10.1128/JVI.70.2.985-991.1996. PMC 189903. PMID 8551639.
^ Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology. 80 (2): 333–9. doi:10.1099/0022-1317-80-2-333. PMID 10073692.

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[pmid8030243-1] Kattoura MD, Chen X, Patton JT (August 1994). "The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase". Virology. 202 (2): 803–813. doi:10.1006/viro.1994.1402. PMID 8030243.

[pmid8551639-2] Aponte C, Poncet D, Cohen J (February 1996). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2". Journal of Virology. 70 (2): 985–91. doi:10.1128/JVI.70.2.985-991.1996. PMC 189903. PMID 8551639.

[pmid10073692-3] Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology. 80 (2): 333–9. doi:10.1099/0022-1317-80-2-333. PMID 10073692.

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