Nephronectin

NPNT
Identifiers
Aliases	NPNT, EGFL6L, POEM, nephronectin
External IDs	OMIM: 610306; MGI: 2148811; HomoloGene: 14138; GeneCards: NPNT; OMA:NPNT - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	106,004,027 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	132,656,052 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lung; ; jejunal mucosa; ; right coronary artery; ; Descending thoracic aorta; ; ascending aorta; ; lower lobe of lung; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	ascending aorta; ; epithelium of lens; ; aortic valve; ; left lung lobe; ; tunica media of zone of aorta; ; right lung lobe; ; calvaria; ; medullary collecting duct; ; molar; ; efferent ductule;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; integrin binding; extracellular matrix structural constituent;
Cellular component	membrane; smooth muscle contractile fiber; extracellular matrix; integrin alpha8-beta1 complex; extracellular region; basement membrane; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; ureteric bud development; establishment of protein localization; cellular response to tumor necrosis factor; extracellular matrix organization; cell-cell adhesion mediated by integrin; multicellular organism development; branching involved in ureteric bud morphogenesis; positive regulation of osteoblast differentiation; cell adhesion; pilomotor reflex; positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; positive regulation of alkaline phosphatase activity; positive regulation of ERK1 and ERK2 cascade; cell-matrix adhesion; positive regulation of smooth muscle contraction; positive regulation of cell-substrate adhesion;
	Sources:Amigo / QuickGO
Orthologs
	255743
	114249
	ENSG00000168743
	ENSMUSG00000040998
	Q6UXI9
	Q91V88
NM_001033047; NM_001184690; NM_001184691; NM_001184692; NM_001184693;
	NM_198278
	NM_001029836; NM_001287101; NM_001287102; NM_001287103; NM_033525
	NP_001028219; NP_001171619; NP_001171620; NP_001171621; NP_001171622
	NP_001025007; NP_001274030; NP_001274031; NP_001274032; NP_277060
	Wikidata
View/Edit Human	View/Edit Mouse

Nephronectin is a protein that in humans is encoded by the NPNT gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168743 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040998 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Nephronectin". Retrieved 2017-10-07.

Kahai S, Lee SC, Lee DY, Yang J, Li M, Wang CH, Jiang Z, Zhang Y, Peng C, Yang BB (2009). "MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7". PLOS ONE. 4 (10): e7535. Bibcode:2009PLoSO...4.7535K. doi:10.1371/journal.pone.0007535. PMC 2760121. PMID 19844573.
Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ (2010). "Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function". Nat. Genet. 42 (1): 45–52. doi:10.1038/ng.500. PMC 2832852. PMID 20010835.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP (2010). "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts". Hum. Mol. Genet. 19 (12): 2497–506. doi:10.1093/hmg/ddq112. PMC 2876884. PMID 20332099.
Nakatani S, Wei M, Ishimura E, Kakehashi A, Mori K, Nishizawa Y, Inaba M, Wanibuchi H (2012). "Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis". Nephrol. Dial. Transplant. 27 (5): 1889–97. doi:10.1093/ndt/gfr682. PMID 22172726.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

Zdroj:https://en.wikipedia.org?pojem=Nephronectin
Text je dostupný za podmienok Creative Commons Attribution/Share-Alike License 3.0 Unported; prípadne za ďalších podmienok. Podrobnejšie informácie nájdete na stránke Podmienky použitia.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168743 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040998 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nephronectin". Retrieved 2017-10-07.

[1]

[2]

[3]

[4]

[5]

References

Further reading