Primidolol

Primidolol
Names
	IUPAC name 1-2-Hydroxy-3-(2-methylphenoxy)propylaminoethyl-5-methylpyrimidine-2,4-dione
Identifiers
CAS Number	67227-55-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	61835;
KEGG	C11774;
PubChem CID	68563;
UNII	56QH73D78K ;
CompTox Dashboard (EPA)	DTXSID0043840 ;
	InChI InChI=1S/C17H23N3O4/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23) Key: RETPFDTUCPKFEC-UHFFFAOYSA-N;
	SMILES CC1=CC=CC=C1OCC(CNCCN2C=C(C(=O)NC2=O)C)O;
Properties
Chemical formula	C17H23N3O4
Molar mass	333.388 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C 77 °F, 100 kPa). Infobox references

Primidolol is a beta adrenergic receptor antagonist.^[1]^[2]^[3]

Referencesedit

^ Saltvedt, E; Fauchald, P (1980). "Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension". Current Medical Research and Opinion. 6 (8): 528–33. doi:10.1185/03007998009109482. PMID 6104564.
^ Augstein, J.; Cox, D. A.; Ham, A. L.; Leeming, P. R.; Snarey, M. (1973). "Beta-adrenoceptor blocking agents. 1. Cardioselective 1-aryloxy-3-(aryloxyalkylamino)propan-2-ols". Journal of Medicinal Chemistry. 16 (11): 1245–1251. doi:10.1021/jm00269a007. PMID 4147835.
^ DE 2238504, Augstein, Joachim; Cox, David Alexander & Ham, Allan Leslie, "Propanolaminderivate Propanolamine derivates", published 1973-02-22, assigned to Pfizer Corp.

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[1] Saltvedt, E; Fauchald, P (1980). "Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension". Current Medical Research and Opinion. 6 (8): 528–33. doi:10.1185/03007998009109482. PMID 6104564.

[2] Augstein, J.; Cox, D. A.; Ham, A. L.; Leeming, P. R.; Snarey, M. (1973). "Beta-adrenoceptor blocking agents. 1. Cardioselective 1-aryloxy-3-(aryloxyalkylamino)propan-2-ols". Journal of Medicinal Chemistry. 16 (11): 1245–1251. doi:10.1021/jm00269a007. PMID 4147835.

[3] DE 2238504, Augstein, Joachim; Cox, David Alexander & Ham, Allan Leslie, "Propanolaminderivate Propanolamine derivates", published 1973-02-22, assigned to Pfizer Corp.

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