SLC34A1

SLC34A1
Identifiers
Aliases	SLC34A1, NPT2, NPTIIa, solute carrier family 34 member 1, NaPi-2a, HCINF2, SLC17A2, SLC11, NAPI-3, FRTS2, NPHLOP1
External IDs	OMIM: 182309; MGI: 1345284; HomoloGene: 20663; GeneCards: SLC34A1; OMA:SLC34A1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,398,848 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,563,405 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; metanephric glomerulus; ; renal medulla; ; right lobe of liver; ; human kidney; ; granulocyte; ; blood; ; mucosa of esophagus; ; tonsil; ; zone of skin;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; clavicle; ; membranous bone; ; maxilla; ; mandible; ; lumbar subsegment of spinal cord; ; rib; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein binding; symporter activity; sodium:phosphate symporter activity; PDZ domain binding; protein-containing complex binding;
Cellular component	integral component of membrane; endosome; membrane; intrinsic component of plasma membrane; integral component of plasma membrane; cell surface; brush border membrane; perinuclear region of cytoplasm; membrane raft; vesicle; brush border; cytoplasm; plasma membrane; apical plasma membrane; nuclear speck; mitotic spindle;
Biological process	phosphate ion transport; response to potassium ion; response to estradiol; cellular response to staurosporine; glycoprotein metabolic process; response to cadmium ion; ossification; sodium-dependent phosphate transport; positive regulation of phosphate transmembrane transport; kidney development; response to nutrient; sodium ion transport; response to thyroid hormone; response to peptide hormone; phosphate ion homeostasis; response to magnesium ion; dentinogenesis; response to peptide; response to vitamin A; indole metabolic process; cellular response to metal ion; response to parathyroid hormone; response to lead ion; tricarboxylic acid metabolic process; gentamycin metabolic process; response to growth hormone; arsenate ion transmembrane transport; response to mercury ion; cellular response to parathyroid hormone stimulus; positive regulation of sodium-dependent phosphate transport; positive regulation of membrane potential; protein homooligomerization; cellular phosphate ion homeostasis; sodium ion transmembrane transport; ion transport; phosphate ion transmembrane transport; sodium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	6569
	20505
	ENSG00000131183
	ENSMUSG00000021490
	Q06495; Q7Z725
	Q60825; Q9D2V6
	NM_001167579; NM_003052
	NM_011392
	NP_001161051; NP_003043; NP_003043.3
	NP_035522
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium-dependent phosphate transport protein 2A, also known as Na⁺-P_i cotransporter 2a (NaPi-2a), is a protein in humans that is encoded by the SLC34A1 gene.^[5] This gene encodes a member of the type II sodium-phosphate cotransporter family.

Function

The sodium/phosphate cotransporter is a protein found in the proximal tubule of the nephron. It is responsible for reabsorbing approximately 80% of the phosphate that has been filtered out at the glomerulus. The transporter moves hydrogen phosphate (HPO₄²⁻) into the cell along with 3 sodium ions. Alternatively it can move dihydrogen phosphate (H₂PO₄⁻ along with 2 sodium ions. For both movements the net charge is +1. Once inside the cell hydrogen phosphate and dihydrogen phosphate may react with water to form each other. Transport of these chemicals out of the cell at the basolateral surface is not understood currently.^[6]

The NaPi channels are regulated by parathyroid hormone (PTH). PTH acts to decrease phosphate reabsorption from the renal filtrate and therefore promote its excretion into the urine. It does this by causing for endocytosis of NaPi transporters on the apical surface of the cell. With less transporter available more phosphate is lost in the urine.^[6]

Clinical significance

Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131183 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021490 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Solute carrier family 34 (sodium phosphate), member 1".
^ ^a ^b Boron WF, Boulpaep EL (2012). Medical Physiology: a cellular and molecular approach (2 ed.). Philadelphia: Saunders. ISBN 978-1-4377-1753-2.

External links

Sodium-Phosphate+Cotransporter+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131183 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021490 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 34 (sodium phosphate), member 1".

[isbn1-4377-1753-5-6] Boron WF, Boulpaep EL (2012). Medical Physiology: a cellular and molecular approach (2 ed.). Philadelphia: Saunders. ISBN 978-1-4377-1753-2.

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Function

Clinical significance

See also

References

Further reading

External links