KCNU1

KCNU1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HPF
Identifiers
Aliases	KCNU1, KCNMC1, KCa5, KCa5.1, Kcnma3, Slo3, potassium calcium-activated channel subfamily U member 1
External IDs	OMIM: 615215; MGI: 1202300; HomoloGene: 7392; GeneCards: KCNU1; OMA:KCNU1 - orthologs
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	26,427,967 bp
RNA expression pattern
	Top expressed in
	sperm; ; bone marrow cells; ; caput epididymis; ; substantia nigra; ; monocyte; ; mammary gland; ; breast; ; subcutaneous adipose tissue; ; male reproductive gland; ; prostate;
	Top expressed in
	spermatid; ; morula; ; lumbar spinal ganglion; ; seminiferous tubule; ; spermatocyte; ; facial motor nucleus; ; blastocyst; ; islet of Langerhans; ; embryo; ; anterior horn of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated potassium channel activity; large conductance calcium-activated potassium channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; calcium-activated potassium channel activity; outward rectifier potassium channel activity;
Cellular component	integral component of membrane; voltage-gated potassium channel complex; plasma membrane; membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; ion transport; transmembrane transport; potassium ion transmembrane transport; sperm-egg recognition; reproductive process; regulation of membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	157855
	16532
	n/a
	ENSMUSG00000031576
	A8MYU2
	O54982
	NM_001031836
	NM_008432
	NP_001027006
	NP_032458
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the K_Ca5.1 protein.^[4]

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031576 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K⁺ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.
^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K⁺ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K⁺ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

External links

Overview of all the structural information available in the PDB for UniProt: A8MYU2 (Potassium channel subfamily U member 1) at the PDBe-KB.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Schreiber M, Wei A, Yuan A, et al. (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. Bibcode:2006Natur.439..331N. doi:10.1038/nature04406. PMID 16421571.
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031576 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9452476-4] Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K⁺ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.

[Wei-5] Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.

[pmid16940554-6] Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K⁺ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.

[pmid16940555-7] Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K⁺ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.

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References

External links

Further reading