U-46619

U46619
Names
	Preferred IUPAC name (5Z)-7-{(1R,4S,5S,6R)-6--2-oxabicycloheptan-5-yl}hept-5-enoic acid
Identifiers
CAS Number	56985-40-1 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL357834 ;
ECHA InfoCard	100.164.944
IUPHAR/BPS	1888;
PubChem CID	5311493;
CompTox Dashboard (EPA)	DTXSID601028475 ;
	SMILES CCCCC(O)/C=C/12OC(C2)1C/C=C\CCCC(O)=O;
Properties
Chemical formula	C21H34O4
Molar mass	350.49 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). verify (what is ?) Infobox references

U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH₂ first prepared in 1975,^[1] and acts as a thromboxane A₂ (TP) receptor agonist. It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations and exhibits many properties similar to thromboxane A₂, including shape change and aggregation of platelets ^[2] and smooth muscle contraction. U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin.^[3]

References

^ Bundy, G. L. (1975). "Synthesis of prostaglandin endoperoxide analogs". Tetrahedron Letters. 16 (24): 1957–1960. doi:10.1016/S0040-4039(00)72333-1.
^ Liel, N.; Mais, D.E.; Halushka, P.V (1987). "Binding of a thromboxane A2/prostaglandin H2 agonist U46619 to washed human platelets". Prostaglandins. 33 (6): 789–797. doi:10.1016/0090-6980(87)90107-9. PMID 2959986.
^ Burch, Ronald M.; Halushka, Perry V. (1983). "Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport". Journal of Pharmacology and Experimental Therapeutics. 224 (1): 108–17. PMID 6294273.

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[1] Bundy, G. L. (1975). "Synthesis of prostaglandin endoperoxide analogs". Tetrahedron Letters. 16 (24): 1957–1960. doi:10.1016/S0040-4039(00)72333-1.

[2] Liel, N.; Mais, D.E.; Halushka, P.V (1987). "Binding of a thromboxane A2/prostaglandin H2 agonist U46619 to washed human platelets". Prostaglandins. 33 (6): 789–797. doi:10.1016/0090-6980(87)90107-9. PMID 2959986.

[3] Burch, Ronald M.; Halushka, Perry V. (1983). "Calcium-45 fluxes in isolated toad bladder epithelial cells: effects of agents which alter water or sodium transport". Journal of Pharmacology and Experimental Therapeutics. 224 (1): 108–17. PMID 6294273.

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